The in vitro and in vivo effects of human growth hormone administration on tumor growth of rats bearing a transplantable rat pituitary tumor (7315b).

SWJ. The in vitro and in vivo effects of hum an growth hormone administration on tum or growth of rats bearing a transplantable rat pituitary tumor (7315b)- Eur J Cancer

Human Wharton’s jelly mesenchymal stem cells-derived secretome could inhibit breast cancer growth in vitro and in vivo

Objective(s): Controversial results have been reported regarding the anti-tumor properties of extracellular vesicles derived from mesenchymal stem cells (MSCs). The present study was conducted to evaluate whether secretome derived from Human Wharton’s jelly mesenchymal stem cells (hWJMSCs) may stimulate or inhibit breast cancer growth in vitro and in vivo.<st...

Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo

Background: Chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. In vitro studies have been shown that Arteether (ARE) induces apoptosis in tumor cells, but not in normal cells. Objective: To investigate the cytotoxic and immunomodulatory properties of Arteether in-vivo and in-vitro. Methods: In this study, we ...

Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model

Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the express...

Percoll Density Gradient Centrifugation of Rat Pituitary Tumor Cells: a Study of Functional Heterogeneity Within and Between Tumors With Respect to Growth Rates, Prolactin Production and Responsiveness to the Somatostatin Analog SMS

Tumor cells prepared from PRL-secreting rat pituitacy 73 156 tumors qf increa.ting weight were separated on continuous Percoll density gradients, according to d$jerences in their density. Whether the cell subpopulations obtained E$ dens& gradient separation .\hou,ed differences in protein content per cell, PRL production per cell, groutth rates and respon.kenej.c to the somatostatin analog SMS ...